Dr. Lucien C. Alexandre, MD PhD


Pain Management Doctor

Dr. Lucien C. Alexandre, MD PhD, is a triple board-certified interventional pain doctor and neurologist.

Dr. Alexandre studied neural science at New York University, where he was a research fellow in the Howard Hughes Research program. He then earned both a Doctorate of Medicine (MD) and a Doctorate of Philosophy (PhD) as well as a Master’s degree (MS) in Neuroscience from Albert Einstein College of Medicine in New York. He later completed his neurology residency at the University of Miami/Jackson Memorial Hospital and his fellowship training in pain medicine at the Harvard University Medical School Beth Israel Deaconess Medical Center in Boston with additional training at Brigham and Women’s Hospital and Boston’s Children’s hospital. He is triple board certified in interventional pain medicine, interventional headache and neurology.

With vast academic experience, real-world training, and a professional portfolio at some of the world’s most prestigious medical institutions, Dr. Alexandre is recognized as one of the premiere experts in the field with a reputation for being a meticulous interventional pain medicine doctor with in-depth understanding of the brain, nerves and pain, which he combines with his passion for disorders of the nervous system and methods for pain management.

He has experience treating thousands of patients and has never shied away from difficult or tough to treat pain conditions and offers an interdisciplinary approach to helping patients get back to living a fuller life. He is based in Broward, FL, and is fluent in English, Spanish, French and Creole.

Areas of expertise:

  • 3 Board Certifications
  • Harvard Trained Interventional Pain Management Doctor
  • 10 years of experience

Dr. Alexandre specializes in advanced interventional procedures with safety as the number one concern. In addition to his extensive education, Dr. Alexandre is trained in and employs state-of-the-art instruments and interventional procedures.

  • Spinal Cord Stimulator Trial and Implants
  • Peripheral Nerve Stimulation
  • Kyphoplasty, Spine Jack ™ and vertebroplasty
  • Minimally invasive lumbar decompression and interspinous spacers
  • Radiofrequency and cryoablative procedures
  • Intrathecal pump implants


  • Alexandre, L., Gilligan, C. (2021). ‘Emergencies in Pain Medicine’, in Brenner, G.J. and Rathmell, J.P. (eds.) The Massachusetts General Hospital Handbook of Pain Management 4 th edition. Philadelphia:Wolters Kluwer, pp. 568-577.
  • Noor N, Urits I, Viswanath O, Alexandre L, Kaye A. Radiofrequency Ablation of Splanchnic Nerve and Superior Hypogastric Plexus for Chronic Abdominal Pain Status Post Abdominal Surgery. Cureus. 2020 Dec; 12(12): e12189
  • Sakellariou A, Alexandre L, Gill J, Simopoulous T. Spinal Cord Stimulation in the Treatment of Neuropathic Pain Associated with Syrinx Developed after Cervical Epidural Steroid Injection. PMCR. 2020; 4:113-119.
  • Kassem H, Alexandre L, Urits I, Kaye AD, Viswanath O. Mandibular Nerve Block for Long-Term Pain Relief in a Case of Refractory Burning Mouth Syndrome. Pain Ther. 2020 Jun 9(1):345-347.
  • Lizarraga KJ, Alexandre LC, Ramos-Estebanez C, Merenda A. Are steroids a beneficial adjunctive therapy in the immunosuppressed patient with Herpes Simplex Virus Encephalitis? Case Rep Neurol. 2013 Mar 21:5(1):52-5.
  • John K. Houten, M.D., Lucien C. Alexandre, Ph.D., Rani Nasser, M.D., and Adam L. Wollowick, M.D. Nerve Injury During Transpsoas Approach for Lumbar Fusion. Report of 2 Cases and Review of the Literature. J. Neurosurg: Spine Sep;15(3):280-4. Epub 2011 May 27.
  • Molero AE, Gokhan S, Gonzalez S, Feig JL, Alexandre LC, Mehler MF. Impairment of developmental stem cell-mediated striatal neurogenesis and pluripotency genes in a knock-in model of Huntington’s disease. Proc Natl Acad Sci U S A. 2009 Dec 22;106(51):21900-5.
  • Aoki C, Miko I, Oviedo H, Mikeladze-Dvali T, Alexandre L, Sweeney N, Bredt DS. Electron microscopic immuno-cytochemical detection of PSD-95, PSD-93, SAP-102, and SAP-97 at postsynaptic, presynaptic, and nonsynaptic sites of adult and neonatal rat visual cortex. Synapse. 2001 Jun 15;40(4):239-57.


  • Kassem H, Schwartz R, Alexandre L. 2019. Development of isolated femoral neuropathy following cryoablation of genitofemoral nerve in a patient with chronic genitofemoral neuralgia. ASRA. New Orleans, LA.
  • Kassem H, Schwartz R, Peck J, Alexandre L. 2019. Utilization of mandibular nerve block for long-term pain relief in a case of refractory burning mouth syndrome. 44 Th Annual Reg. Anesth. & Acute Pain Med. Las Vegas, NV.
  • Alexandre L, Keeler B, Zhuang Z, Levitt R. 2015. Inter-strain Variability in Susceptibility to Persistent Pain After Nerve Injuries in Mus Musculus. Am. Acad. of Pain Med. Abstr. 31. National Harbor, MD.
  • Miller T, Steinberger J, Alexandre L, Burns J, Brook A. 2014. Long Term Follow-up of Patients with Symptomatic Synovial Cysts. 75% Treated with Percutaneous Rupture do not Require Surgical Treatment. Am. Soc. Spine Rad. Abstr. 12. Miami Beach, FL.
  • Erisir A, Alexandre L. 2000. End of critical period is concurrent with the reduction of NR2B subunit from synapses. Soc. Neurosci. Abstr. 26. New Orleans, LA.
  • Aoki, C., Oviedo, H., Alexandre, L., and Bredt, DS. 1999. Synaptic, membranous and cytoplasmic localization of PSD-95: EM-immunocytochemical detection within intact developing cortical neuropil. Soc. Neurosci. Abstr. 25.
  • Aoki C, Shusterman Z, Kasat M, Bak M, Alexandre L, and Bredt DS. 1998. Subcellular localization of SAP97, PSD-95, PSD-93 and a novel PSD-95 binding protein, 47k, at synaptic and nonsynaptic sites in intact visual cortex: an EM-immuno-cytochemical study. Soc. Neurosci. Abstracts 24: 1802.

Professional Affiliations:

  • American Academy of Pain Medicine
  • American Society of Interventional Pain Physicians
  • American Society of Pain and Neuroscience
  • North American Neuromodulation Society
  • American Academy of Neurology
  • American Interventional Headache Society
  • Boston Pain Society (Board of Directors)

Contact Detail

3661 S Miami Ave Suite 106 Miami, FL 33133

Phone (305) 701-7168

Fax (305) 701-7167

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